Some companies have their shares of stock, which are pieces of the company that people can buy and sell. When a company's stock price goes down a lot, it is called a "loser". When a company's stock price goes up a lot, it is called a "winner".
SeaStar Medical Holding Corporation is a company that makes medical devices, and they had to sell a lot of their stock to raise money. This made their stock price go down by 34%.
There are other companies that had big changes in their stock prices today. Some went up a lot, and some went down a lot. Some examples are Virpax Pharmaceuticals, Kazia Therapeutics, Longeveron, and VivoPower International.
When a company's stock price changes a lot, it can be because of good news, bad news, or something else happening that makes people want to buy or sell the stock more. Sometimes, it can be hard to tell why a stock price changed, but it can be interesting to watch and learn about different companies.
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